Turn the cap around and place the other end of the cap back on the tube. The chemical name for imidacloprid is 1-[(6-Chloro-3- pyridinyl)methyl]-N-nitro-2-imidazolidinimine. To report a suspected adverse reaction, call 1-800-422-9874. How Long Does It Take to Receive My Advantage Multi Order? Dermal Safety Study in Ivermectin-Sensitive Collies:Advantage Multi for Dogs was administered topically at 3 and 5X the recommended dose every 28 days for 3 treatments to Collies which had been pre-screened for avermectin sensitivity. or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. Do not dispense dose applicator tubes without complete safety and administration information. CAUTION: Federal (U.S.A.) law restricts Advantage Multi ® for Dogs to use by or on the order of a licensed veterinarian.. Part the hair on the back of the dog between the shoulder blades until the skin is visible. The safe use of Advantage Multi for Dogs has not been established in puppies and dogs less than 7 weeks of age or less than 3 lbs. Avoid contact with skin. More on Flea Treatments When replacing another heartworm preventative product in a heartworm prevention program, the first treatment with Advantage Multi for Dogs should be given within one month of the last dose of the former medication. You need to use it on every animal you keep in the house. Heartworm Prevention: For prevention of heartworm disease, Advantage Multi for Dogs should be administered at one-month intervals. Before applying, check the weight range and minimum age on the package to choose the appropriate product for your dog. Whether this actually occurs to a moderately high degree (70-80% flea kills at 28 days) or a really high degree (>90% flea kills at 28 days), however, depends on the study you look at. Laboratory Effectiveness Studies: One dog in a laboratory effectiveness study experienced weakness, depression, and unsteadiness between 6 and 9 days after application with Advantage Multi for Dogs. P.O. Advantage® II for dogs combines two active ingredients: This combination plays a crucial role in treating and preventing infestations, because: Advantage® II flea prevention is applied to your dog topically, spreading over the skin and hair. Causes eye irritation. WARNING: DO NOT ADMINISTER THIS PRODUCT ORALLY. (See ANIMAL SAFETY: – SafetyStudy in Heartworm-Positive Dogs.). With oral flea medications, fleas have to bite your dog and ingest the medication before they are killed. Advantage Multi – A Potent Parasitic Preventative October 31, 2019 October 31, 2019 Taking care of dogs is an arduous task; from their food to their daily routine, they are entirely dependent on you. Have person sip a glass of water if able to swallow. Twist the cap to break the seal, and then remove the cap from the tube. Keep in mind that more frequent bathing may keep the product from working the full 30 days. One dog showed signs of treatment site irritation after application. Do not contaminate water, food or feed by storage or disposal of Advantage® II. Twist the cap to break the seal and then remove cap from the tube. Your dog is free to take a dip after Advantage. Can I apply Advantage® II for dogs on my cats? The formula is waterproof so there is no need for reapplication after bathing your dog or taking your pet for a swim. However, shampooing as often as once weekly may reduce the effectiveness of the product against fleas. Six dogs vomited within 1 hour of receiving the test article, 2 of these dogs vomited again at 2 hours, and 1 dog vomited again up to 18 hours post-dosing. CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian. Field Studies: Following treatment with Advantage Multifor Dogs or an active control, dog owners reported the following post-treatment reactions: During a field study using 61 dogs with pre-existing flea allergy dermatitis, one (1.6%) dog experienced localized pruritus immediately after imidacloprid application, and one investigator noted hyperkeratosis at the application site of one dog (1.6%). Advantage 40 Flea Treatment should be used for smaller cats, small dogs and rabbits. Two dogs vomited, one at 6 hours and one at 6 days post-treatment. The other thing that should concern everyone is that Advocate/Advantage-Multi is labelled for use once a month — and yet all these vets are … Do not use this product (containing 2.5% moxidectin) on cats. At 5X, one dog was observed vomiting three hours after the second treatment. Dermal Dose Tolerance Study: Advantage Multi for Dogs was administered topically to 8-month-old Beagle dogs at 10X the recommended dose once. No, do not use Advantage® II for dogs on cats. HOW LONG DOES A DOSE LAST? (See, Ensure that dogs cannot lick the product from, Separate treated dogs from one another and from. Do not get in eyes or on clothing. Treatment and Control of Intestinal Nematode Infections: For the treatment and control of intestinal hookworm infections caused by Ancylostoma caninum and Uncinariastenocephala (adults, immature adults and fourth stage larvae) and roundworm infections caused by Toxocara canis (adults and fourth stage larvae), and Toxascaris leonina (adults), and whipworm infections caused by Trichuris vulpis (adults), Advantage Multi for Dogs should be administered once as a single topical dose. Imidacloprid is a chloronicotinyl nitroguanidine insecticide. Yes! 1 Product Label. Hypersensitivity reactions were not seen in the 5X treatment group. Both Advantage and the new Advantage II last for a full month after application. How long does Advantage® II for dogs take to work? Generic Name: imidacloprid moxidectin solution Use Advantage® II for dogs monthly, year-round to help keep your pet protected from fleas. Advantage Multi ® for Dogs prevents heartworm disease in dogs after a swim or bath, 60 and 90 minutes respectively after application. Collagen is not a magical supplement, and it does not work a miracle overnight. If partly filled: Call your local solid waste agency for disposal instructions. Advantage is a registered trademark of Bayer. See the Product Label for specific application instructions by weight. more severe and may include coma and death.2. Flea Treatment: For the treatment of flea infestations, Advantage Multi for Dogs should be administered at one-month intervals. In case of allergic reaction, contact a physician. Bayer HealthCare LLC However, if the dog has a severe infestation, retreatment within a month may be necessary. application sites for two (2) hours after application. The Material Safety Data Sheet (MSDS) provides additional occupational safety information. (See CONTRAINDICATIONS.). Remove the tube from packaging and open it by putting the cap on the other end and twisting to break the seal. Disposal and Container Handling: Non-refillable container. Advantage is applied as one dose to your dog's skin. For someone who unfortunately has health challenges, glandulars provide nutrients not found in plants and they don’t create any negative reaction that could occur from taking plant material. (See WARNINGS.). Healthy, active people already take a multi-vitamin, a multi-mineral, or a multi-enzyme. Trifexis is a once a month oral medication. Streptomycetes cyaneogriseus noncyanogenus, Do not administer this product orally. Storage Store at room temperature away from children and pets. Pyriproxyfen is an insect growth regulator (IGR) that kills flea eggs and larvae. Part the hair on your dog’s back, between the shoulder blades, until the skin is visible. Moxidectin is a semisynthetic macrocyclic lactone endectocide derived from the actinomycete Streptomycetes cyaneogriseus noncyanogenus. Oral Safety Study in Ivermectin-Sensitive Collies: Advantage Multi for Dogs was administered orally to 5 pre-screened ivermectin-sensitive Collies. So fleas do not have to bite your dog to die. If the dog is already infested with fleas when the first dose of Advantage Multi for Dogs is administered, adult fleas on the dog will be killed. To further break down the Advantage … The tablet is beef flavored so your dog should readily accept it as a treat. Follow label directions for application. AdvantageMulti for Dogs is not effective against adult D. immitis. Dosage Form: FOR ANIMAL USE ONLY. Storage: Store in a cool, dry place. (See CONTRAINDICATIONS.). Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. One puppy in the 1X treatment group had pruritus for one hour following the fifth treatment. Advantage Multi for Dogs may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. What’s the difference between Advantage® II for dogs and oral flea products? If you choose to bathe your dog in between treatments, we recommend use of a general grooming shampoo for pets. The recommended minimum dose is 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin, once a month, by topical administration. Prevents and treats: Kills fleas at multiple life stages. Do not allow the dog to lick any of the application sites for30 minutes. For more detailed instructions, watch our application video. Cats up to 9 pounds – 0.4 ml. Prevents fleas on treated dogs from infesting your home, Prevents flea re-infestation by breaking the flea life cycle for 30 days, Treats, prevents and controls lice infestations. Shampooing or water immersion 4 days after treatment will not reduce the effectiveness of Advantage Multi for Dogs in the treatment of flea infestations. Hold the applicator tube in an upright position facing away from you and your pet’s face and eyes. Keep out of the reach of children. See product label for additional information. Puppies younger than 7 weeks of age and pregnant dogs should not use Advantage. If the dog is already infested with fleas when the first dose of Advantage Multi for Dogs is administered, adult fleas on the dog will be killed. Advantage flea medication is a medication made for dogs that prevents fleas, flea eggs, and lice. Call a poison control center or physician for treatment advice. ADVANTAGE AND ADVANTAGE II DOSAGE CHART. application sites on themselves or other treated dogs, and. Feb 14, 2015. 08891454 6 x 0.4 mL tubes, 08891462 6 x 1.0 mL tubes, 08891470 6 x 2.5 mL tubes, 08891489 6 x 4.0 mL tubes, 80560290 6 x 5.0 mL tubes. Immature flea life stages which live in the pet's environment consist of around 95% of the infestation and can be almost invisible to the naked eye. Yes! Harmful if swallowed. Remove one dose applicator tube (tube) from the package. Just make sure your dog is dry before application. The signs resolved without intervention by day 10 post-application. Adverse events reported in dogs topically treated with imidacloprid + moxidectin for dogs included: vomiting, diarrhea, bloody diarrhea, salivation, poor appetite, lethargy, weakness, restlessness, agitation, disorientation, ataxia, muscle tremors, seizures, panting, labored breathing, acute pulmonary edema, hives, rash, swollen face and ears, pruritus, erythema, alopecia, hot spots, local discomfort, and discoloration of the hair at the application site. Make sure it never comes up by protecting your cat every month. In a controlled, double-masked, field safety study, AdvantageMulti for Dogs was administered to 128 dogs of various breeds, 3 months to 15 years of age, weighing 4 to 157 pounds. Your dog should be standing for easy application. I totally agree with DLB, Advantage, if used properly (follow instructions), takes effect inside the first 48 hours. Select your pet to receive relevant content. Break the flea life cycle for 30 days. Accidental oral ingestion in dogs caused salivation, vomiting, muscle tremor, seizures, mydriasis, ataxia, lethargy, disorientation, agitation, and poor appetite. It kills fleas through contact, so fleas do not have to bite your dog to die. Microfilariae counts decreased with treatment. Keep out of reach of children. Do not induce vomiting unless told to do so by the poison control center or physician. Loose stools and diarrhea were observed in all groups, including the controls, throughout the study. Safety Study in Puppies: Advantage Multi for Dogs was applied topically at 1, 3 and 5X the recommended dose to 7-week-old Beagle puppies once every 2 weeks for 6 treatments on days 0, 14, 28, 42, 56, and 70. In avermectin sensitive dogs1, the signs may be Well, I got the Advantage for them, and the flea pill, and they had them about 5 days ago. First you need to set up an account with us, create a payment method, and send us your prescriptions. Foreign Market Experience: Because the following events were reported voluntarily during post-approval use of the product in foreign markets, it is not always possible to reliably establish a causal relationship to drug exposure. Owners reported the following signs in their dogs after application of Advantage Multifor Dogs: pruritus, flaky/greasy residue at the treatment site, medicinal odor, lethargy, inappetence, and hyperactivity. Your dog is free to take a dip after Advantage® II has been on for 24 hours. Advantage Multi ® for Cats and Dogs does have an expiration date that can be found on the bottom edge of the package. The Collies were asymptomatic after ingesting 10% of the minimum labeled dose. One dog exhibited shaking (nervousness) 1 hour post-dosing. If swallowed, call poison control center or physician immediately for treatment advice. Place the tip of the tube on the skin between your dog's shoulder blades and gently squeeze to expel the solution on their skin. Dogs treated with imidacloprid, including those with preexisting flea allergy dermatitis have shown clinical improvement as a direct result of elimination of fleas from the dog. Advantage® II kills fleas through contact, so they don’t have to bite your dog to die. For a copy of the Material Safety Data Sheet (MSDS) or to report adverse reactions call Bayer Veterinary Services at 1-800-422-9874. (See WARNINGS.). Advantage topicals will not protect your pet from ticks-- K9 Advantix for Dogs, however, does protect against ticks. Re-infesting or new fleas are killed within two hours for the remainder of the month. Information about how quickly a medication starts to work is easily available by reading the product label, visiting the manufacturer’s website, or by talking to your veterinarian. It will also kill any fleas, flea larvae, or lice currently on your dog. Safety Study in Heartworm-Positive Dogs: Advantage Multifor Dogs was administered topically at 1 and 5X the recommended dose every 14 days for 3 treatments to dogs with adult heartworm infections and circulating microfilariae. (Oh, I set off flea bombs too, and got us all out of here, for a day) So, when can I bathe them with for fleas--OR do I not need to, even though they … Place in trash or offer for recycling if available. People with known hypersensitivity to benzyl alcohol, moxidectin, or imidacloprid should administer the product with caution. For dogs weighing 20 lbs. Advantage ® II for cats combines two active ingredients:. Advantage® II for dogs kills fleas on dogs within 12 hours of application. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Wash hands thoroughlywith soap and warm water after handling. It works differently for the skin, hair, and joint pains. No clinical abnormalities were observed. The formula kills fleas within 24 hours and … But the amount of time that it takes to work depends on what you are exactly looking for. Our Advantage® family of products can help arm you in the fight against fleas to treat your pet, home and yard. Advantage flea treatment for dogs is an easy-to-apply spot-on treatment that kills fleas within one day, preventing further infestations for up to four weeks. 1. more severe and may include coma and death. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. And by killing eggs and larvae, you can break the flea life cycle. 1 card / 6 doses per card (0.8 mL tubes) — 08891446. However, we suggest bathing your dog before applying Advantage® II. Observations at the application sites included damp, stiff or greasy hair, the appearance of a white deposit on the hair, and mild erythema, which resolved without treatment within 2 to 48 hours. salivation, dilated pupils, incoordination. Top questions about Advantage® II for Dogs, Unlike chewable forms of flea prevention, Advantage, There is no expiration date required on the packaging by the EPA for Advantage. How long does Advantage® II for dogs last? For the first 30 minutes after application: Ensure that dogs cannot lick the product from (Advantage Multi) Common Drug Name Imidacloprid plus moxidectin Common Brand Names Advantage Multi for Cats Advantage Multi for Dogs Note: Advantage Multi for Cats (in the 0.4 mL size only) has now been approved by FDA for some uses in ferrets. Yes. If contact with eyes occurs hold eyelids open and flush with copious amounts of water for 15 minutes. This is true even after baths or swimming, as the Advantage products are waterproof. However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. Turn the cap over and push the other end of cap onto the tip of the tube. Do not allow the dog to lick any of the application sites for. Stiff hair, a damp appearance of the hair, pink skin, or a slight powdery residue may be observed at the application site on some animals. New fleas that jump on the dog from the surroundings, such as grass, carpet and pet bedding, are killed within 2 hours with protection against further infestation for at least 4 weeks. You can use Advantage® II for dogs on puppies and dogs 7 weeks of age and older. How often can you use Advantage® II for dogs? Select one or more newsletters to continue. You can easily place an order on our website in under 5 minutes. Advantage Multi is protected by one or more of the following U.S. patents: 6,232,328, and 6,001,858. So fleas do not have to bite your dog to die. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Two puppies each in the 1X, 3X, and 5X groups had decreased appetites within 24 hours post-dosing. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. Advantage Multi® (imidacloprid + moxidectin), Advantage® Treatment Shampoo for Cats & Kittens, Advantage® Treatment Shampoo for Dogs & Puppies, advantus® soft chew (imidacloprid) for Dogs, Claro® (florfenicol/terbinafine/ mometasone furoate) Otic Solution, Endurosyn® Digestive Health Probiotic Gel for Dogs, Endurosyn® Digestive Health Probiotic Gel for Cats, Free Form™ Omega-3 Fish Oil for Dogs & Cats, Free Form™ Omega-3 Fish Oil for Small Dogs & Cats, Profender® (emodepside/ praziquantel) for Cats, Drontal® Plus (praziquantel/pyrantel pamoate/febantel) for Dogs, Quad Dewormer (praziquantel/pyrantel pamoate/febantel) for Dogs, Tapeworm Dewormer (praziquantel tablets) for Cats, Tapeworm Dewormer (praziquantel tablets) for Dogs, Advantage® Carpet & Upholstery Spot Spray, Advantage® Household Spot & Crevice Spray. Keep in mind that more frequent bathing may keep the product from working the full 30 days. Advantage flea treatment for cats is applied to your cat’s skin and gets to work quickly, killing existing fleas within one day and re-infesting fleas within an hour and for up to a month. K9 Advantix ® II kills fleas within 12 hours. If eye irritation develops or persists, contact a physician. Kills fleas through contact, so fleas don't have to bite your dog to die. Another dog exhibited abnormal neurological signs (circling, ataxia, generalized muscle tremors, and dilated pupils with a slow pupillary light response) starting at 4 hours post-dosing through 18 hours post-dosing. Do not apply an amount of solution at any one location that could run off the side of the dog. Advantage Multi for Dogs is indicated for the prevention of heartworm disease caused by Dirofilaria immitis.Advantage Multi for Dogs kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). Yes. Pull the cap off the tube. Vomiting was seen in one puppy from the 1X treatment group (day 57), in two puppies from the 3X treatment group (days 1 and 79), and in one puppy from the 5X treatment group (day 1). Do not let this product get in your dog’s mouth or eyes. While holding the tube in an upright position, remove the cap from the tube. Freedom of Information Summary: NADA 141-251. Dogs in the treated group did not gain as much weight as the control group. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Do not contaminate water, food or feed by storage or disposal of Advantage. A puppy from the 5X treatment group displayed rapid, difficult breathing from 4 to 8 hours following the second treatment. Separate treated dogs from one another and from other pets to reduce the risk of accidental ingestion. Advantage Flea Treatment remains effective if the animal becomes wet, for example after exposure to heavy rain or after swimming (dogs). 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